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Saldana became known for her work in science fiction films, beginning in 2009 with her first of multiple appearances as Nyota Uhura in the Star Trek film series and her first appearance as Neytiri in the Avatar film series. She has also played Gamora in the Marvel Cinematic Universe, beginning with Guardians of the Galaxy (2014). Due to her appearances in some of the highest-grossing films of all time, she is the second highest-grossing film actress of all time, with her films having collectively grossed more than $10 billion worldwide.

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