Harris has starred in such films as One More Saturday Night, Of Mice and Men (directed by and co-starring her husband), and Terminator 3: Rise of the Machines. She also played the evil trucker's wife in the Kurt Russell movie Breakdown. She has made a guest appearances on the TV shows Karen Sisco, The Equalizer, and Crime Story. At one time, she was a member of the Steppenwolf Theatre Company that Gary Sinise was instrumental in establishing. In 1987 she won a Chicago / Midwest Emmy Award for her role in Murder in Green Meadows. She also starred in Disney's Tall Tale in 1995. Harris retired in 2003.